Degradation of cholesterol in human serum

Cholesterol is a factor contributing to the development of atherosclerosis. Microbes possess enzymatic system for the breakdown of this molecule. We report that the cell-free extract of such a microbe can degrade cholesterol in human serum. To demonstrate this, an assay technique has been devised th...

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Bibliographic Details
Published inBiochemical medicine Vol. 11; no. 3; pp. 290 - 294
Main Authors Geier, Mark R., LaPolla, Robert J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.1974
Subjects
Cholesterol - blood
Cholesterol - metabolism
Colorimetry
Glass
Humans
Kinetics
Nocardia - metabolism
Spectrophotometry
Time Factors
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Summary:Cholesterol is a factor contributing to the development of atherosclerosis. Microbes possess enzymatic system for the breakdown of this molecule. We report that the cell-free extract of such a microbe can degrade cholesterol in human serum. To demonstrate this, an assay technique has been devised that allows serial monitoring of cholesterol levels. The possibility of in vivo application of this enzyme is discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-2944
1557-7996
DOI:10.1016/0006-2944(74)90125-2