Effects of 4-vinylcyclohexene and its main oxirane metabolite on mouse hepatic microsomal enzymes and glutathione levels

When 4-vinylcyclohexene (VCHE) and 4-vinylcyclohexene monoxide (VCM) were administered to mice at 500 mg/kg, cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase and aminopyrine-N-demethylase and epoxide hydrolase were induced. Doses of 500 mg/kg of VCHE, VCM and 4-vinylcyclohexene diepoxid...

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Bibliographic Details
Published inToxicology letters Vol. 8; no. 1-2; p. 115
Main Authors Giannarini, C, Citti, L, Gervasi, P G, Turchi, G
Format Journal Article
LanguageEnglish
Published Netherlands 01.04.1981
Subjects
Animals
Cyclohexanes - adverse effects
Cyclohexanes - metabolism
Cyclohexenes
Enzyme Induction
Epoxide Hydrolases - biosynthesis
Glutathione - analysis
Liver - enzymology
Male
Mice
Microsomes, Liver - enzymology
Vinyl Compounds
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Summary:When 4-vinylcyclohexene (VCHE) and 4-vinylcyclohexene monoxide (VCM) were administered to mice at 500 mg/kg, cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase and aminopyrine-N-demethylase and epoxide hydrolase were induced. Doses of 500 mg/kg of VCHE, VCM and 4-vinylcyclohexene diepoxide depleted rapidly hepatic reduced glutathione levels suggesting that glutathione is probably involved in the metabolism of VCHE.
ISSN:0378-4274
DOI:10.1016/0378-4274(81)90146-6