Effects of 4-vinylcyclohexene and its main oxirane metabolite on mouse hepatic microsomal enzymes and glutathione levels
When 4-vinylcyclohexene (VCHE) and 4-vinylcyclohexene monoxide (VCM) were administered to mice at 500 mg/kg, cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase and aminopyrine-N-demethylase and epoxide hydrolase were induced. Doses of 500 mg/kg of VCHE, VCM and 4-vinylcyclohexene diepoxid...
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Published in | Toxicology letters Vol. 8; no. 1-2; p. 115 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.04.1981
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Subjects | |
Online Access | Get more information |
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Summary: | When 4-vinylcyclohexene (VCHE) and 4-vinylcyclohexene monoxide (VCM) were administered to mice at 500 mg/kg, cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase and aminopyrine-N-demethylase and epoxide hydrolase were induced. Doses of 500 mg/kg of VCHE, VCM and 4-vinylcyclohexene diepoxide depleted rapidly hepatic reduced glutathione levels suggesting that glutathione is probably involved in the metabolism of VCHE. |
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ISSN: | 0378-4274 |
DOI: | 10.1016/0378-4274(81)90146-6 |