GM-CSF is required for the Pseudomonas exotoxin A-induced proliferation of immature T cells in athymic mice

• Published in: Cellular immunology Vol. 160; no. 1; pp. 65 - 70
• Main Authors: Dixon, Diane M., Misfeldt, Michael L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 1995
• Subjects: ADP Ribose Transferases; Animals; Antibodies, Monoclonal - immunology; Bacterial Toxins; Cell Differentiation - immunology; Exotoxins - immunology; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis; Granulocyte-Macrophage Colony-Stimulating Factor - physiology; Interleukin-2 - biosynthesis; Lymphocyte Activation - immunology; Mice; Mice, Nude; Pseudomonas aeruginosa Exotoxin A; Spleen - cytology; T-Lymphocytes - immunology; Thy-1 Antigens - immunology; Tumor Necrosis Factor-alpha - biosynthesis; Virulence Factors

Previous studies have demonstrated that Pseudomonas exotoxin A stimulated the proliferation of immature T lymphocytes within the splenocytes of athymic mice. These studies were performed to determine which lymphokines were involved in the proliferation of the immature T cells. The results of this st...