Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules a...

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Bibliographic Details
Published inBiochemistry (Moscow) Vol. 70; no. 2; pp. 222 - 230
Main Authors Ross, M F, Kelso, G F, Blaikie, F H, James, A M, Cochemé, H M, Filipovska, A, Da Ros, T, Hurd, T R, Smith, R A J, Murphy, M P
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.02.2005
Subjects
Bioenergetics
Cations
Cations - chemistry
Cations - metabolism
Energy Metabolism - physiology
Free radicals
Free Radicals - metabolism
Humans
Intracellular Membranes - metabolism
Mitochondria - metabolism
Mitochondria - physiology
Models, Biological
Molecular Structure
Organophosphorus Compounds - chemistry
Organophosphorus Compounds - metabolism
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Summary:Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.
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ISSN:0006-2979
1608-3040
0320-9725
DOI:10.1007/s10541-005-0104-5