Inhibition of experimental porphyria with colchicine

1. 1. Colchicine at the concentrations of 5 × 10 −7−5 × 10 −6M decreased significantly both delta-aminolevulinic acid synthase activity and accumulation of porphyrins in monolayers of chick embryo liver cells induced by allyl-isopropylacetamide, by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or by phe...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of biochemistry Vol. 17; no. 8; pp. 937 - 940
Main Authors Wysenbeek, A.J., Schoenfeld, N., Epstein, O., Greenblat, Y., Atsmon, A.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 1985
Subjects
5-Aminolevulinate Synthetase - analysis
Animals
Cells, Cultured
Chick Embryo
Colchicine - pharmacology
Colchicine - therapeutic use
Female
Porphyrias - prevention & control
Porphyrins - metabolism
Rats
Rats, Inbred Strains
Online AccessGet full text

Cover

More Information
Summary:1. 1. Colchicine at the concentrations of 5 × 10 −7−5 × 10 −6M decreased significantly both delta-aminolevulinic acid synthase activity and accumulation of porphyrins in monolayers of chick embryo liver cells induced by allyl-isopropylacetamide, by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or by phenobarbitone. 2. 2. No effect was noted in non-induced cells. 3. 3. In rats, colchicine 0.3 mg/kg, reduced significantly the allyl-isopropylacetamide induced increase in the activity of delta-aminolevulinic acid synthase in the liver and the concentration of urinary porphyrins while it did not affect these parameters in non-induced rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0020-711X
DOI:10.1016/0020-711X(85)90179-X