The effects of methadone on the social behavior and activity of the rat

Pairs of 80-day-old female rats were given SC injections of either 0, 1, 2.5, or 4 mg/kg of methadone hydrochloride on each of 6 days. Both animals of the pair received the same dose. One hour postinjection, each pair was observed in a circular arena for a five minute period during which the followi...

Full description

Saved in:
Bibliographic Details
Published inPharmacology, biochemistry and behavior Vol. 16; no. 4; pp. 569 - 571
Main Authors Plonsky, Mark, Freeman, Phyllis R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1982
Subjects
Aggression
Aggression - drug effects
Animals
Dose-Response Relationship, Drug
Female
Grooming - drug effects
Humans
Locomotor activity
Methadone
Methadone - pharmacology
Motor Activity - drug effects
Opiates
Rat
Rats
Rats, Inbred Strains
Social Behavior
Opiates
Social behavior
Methadone
Rat
Aggression
Locomotor activity
Online AccessGet full text

Cover

More Information
Summary:Pairs of 80-day-old female rats were given SC injections of either 0, 1, 2.5, or 4 mg/kg of methadone hydrochloride on each of 6 days. Both animals of the pair received the same dose. One hour postinjection, each pair was observed in a circular arena for a five minute period during which the following dependent measures were recorded: total time in contact, latency to initial contact, frequency of aggressive grooms, and locomotor activity. The results indicated that the rats with methadone spent less time in contact, took longer to contact, and aggressively groomed each other less frequently than rats treated with a saline vehicle. Also, the results suggested that the disruption of social behavior produced by methadone was not a reflection of decreased activity levels.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(82)90417-8