Effect of ethyl alcohol on plasma testosterone level in mice

The effect of ethanol ingestion on testicular steroidogenesis in mice was evaluated by measuring plasma testosterone level. Four groups of CBA/J male mice were treated with one of the following doses of ethanol: 1.240, 0.620, 0.310 or 0.155 g ethanol/Kg body weight. A control group was given water....

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Bibliographic Details
Published inSteroids Vol. 23; no. 6; pp. 921 - 928
Main Authors Badr, Fouad M., Bartke, Andrzej
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.1974
Subjects
Animals
Body Weight
Depression, Chemical
Ethanol - administration & dosage
Ethanol - pharmacology
Male
Mice
Mice, Inbred CBA
Organ Size
Radioimmunoassay
Testis - drug effects
Testosterone - blood
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Summary:The effect of ethanol ingestion on testicular steroidogenesis in mice was evaluated by measuring plasma testosterone level. Four groups of CBA/J male mice were treated with one of the following doses of ethanol: 1.240, 0.620, 0.310 or 0.155 g ethanol/Kg body weight. A control group was given water. The data showed no effect of the treatment on testicular weight. The concentration of testosterone in the plasma was significantly reduced in animals treated with alcohol. There was also a significant relationship between the dose of alcohol and the plasma testosterone level, with the decrease in testosterone being from 2 to 18 fold in various groups.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(74)90064-6