Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders

• Published in: Journal of Neural Transmission Vol. 114; no. 8; pp. 1091 - 1095
• Main Authors: Gebhardt, S, Haberhausen, M, Krieg, J-C, Remschmidt, H, Heinzel-Gutenbrunner, M, Hebebrand, J, Theisen, F M
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.08.2007
• Subjects: Adolescent; Adult; Antipsychotic Agents - adverse effects; Appetite - drug effects; Appetite - physiology; Benzodiazepines - adverse effects; Binge eating; Brain - drug effects; Brain - metabolism; Brain - physiopathology; Bulimia Nervosa - chemically induced; Bulimia Nervosa - metabolism; Bulimia Nervosa - physiopathology; Clozapine - adverse effects; Feeding Behavior - drug effects; Feeding Behavior - physiology; Female; Humans; Male; Middle Aged; Obesity - chemically induced; Obesity - metabolism; Obesity - physiopathology; Recurrence; Surveys and Questionnaires
• ISSN: 0300-9564; 1435-1463
• DOI: 10.1007/s00702-007-0663-2

To explore the association between eating disorders (EDs) prior to the use of clozapine/olanzapine (pre-clozapine/olanzapine EDs) and after initiation of these antipsychotics (post-clozapine/olanzapine EDs). Sixty-four consecutively admitted patients receiving clozapine/olanzapine were screened using the M-Composite International Diagnostic Interview (M-CIDI) to identify subjects with pre-clozapine/olanzapine EDs (DSM-IV criteria). We investigated post-clozapine/olanzapine EDs and binge eating behavior using the Questionnaire on Eating and Weight Patterns (QEWP) and used the Naranjo probability scale as objective causality assessment. Post-clozapine/olanzapine EDs were significantly more frequent in patients with pre-clozapine/olanzapine EDs (5 of 6) when compared to patients without pre-clozapine/olanzapine EDs (4 of 58) [chi(2) = 26.29; df = 1; p < 0.001] [odds ratio (OR) 67.5; 95% CI: 6.3-725.8]. According to the Naranjo probability scale, recurrence or deterioration of EDs in patients with prior EDs was definitely (n = 1) or probably (n = 4) related to the intake of clozapine/olanzapine. Clozapine/olanzapine may induce recurrence or deterioration of binge eating symptomatology or full-blown EDs in patients with prior EDs.