Antilung cancer activities of selenium

Selenium is considered an essential trace element in most animal and plant species, although still reported in many texts as a highly toxic material. Epidemiological investigations have reported an inverse relationship between selenium and lung cancer. Explanations of reported observations have resu...

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Bibliographic Details
Published inMedical hypotheses Vol. 23; no. 4; pp. 443 - 447
Main Authors Lange, J.H., Talbott, E.O., Baffone, K.M., Weyel, D.A., Soboslay, E.G., Koros, A.M.C., Sykora, J.L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.08.1987
Subjects
Humans
Lung Neoplasms - prevention & control
Selenium - administration & dosage
Selenium - physiology
United States
Water Supply
United States
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Summary:Selenium is considered an essential trace element in most animal and plant species, although still reported in many texts as a highly toxic material. Epidemiological investigations have reported an inverse relationship between selenium and lung cancer. Explanations of reported observations have resulted in numerous mechanistic theories. Only recently have selenium metabolites involved in excretion been considered potential agents for antilung cancer activity. Anticancer properties have been shown in occupationally exposed copper smelter workers, dietary investigations and experimental studies. Supplementation with selenium of public water supplies, as is currently done with fluoride, is a potential method for increasing the blood concentration. This may permit development of a population prevention strategy against lung cancer and other diseases.
ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(87)90066-1