Chromatographic mobilities and partition coefficients of synthetic corticosteroid glucosiduronates

Analytical data are presented on the free acids, the methyl esters, the methyl ester triacetates and the methyl ester triacetate semicarbazones of C-21 glucosiduronic acid conjugates of six adrenal hormones. Chromatographie mobilities of all of these compounds in three or more solvent systems are gi...

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Bibliographic Details
Published inSteroids Vol. 18; no. 2; pp. 147 - 160
Main Authors Mattox, Vernon R., Goodrich, June E., Vrieze, Wiley D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1971
Subjects
Acetates
Adrenal Cortex Hormones - isolation & purification
Chemical Phenomena
Chemistry
Chromatography, Paper
Corticosterone
Cortisone - isolation & purification
Desoxycorticosterone - isolation & purification
Drug Stability
Fluorometry
Glucuronates - isolation & purification
Glucuronidase
Hydrocortisone - isolation & purification
Hydroxides
Methanol
Methods
Pregnanes - isolation & purification
Quaternary Ammonium Compounds
Semicarbazides
Sodium Hydroxide
Solubility
Solvents
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Summary:Analytical data are presented on the free acids, the methyl esters, the methyl ester triacetates and the methyl ester triacetate semicarbazones of C-21 glucosiduronic acid conjugates of six adrenal hormones. Chromatographie mobilities of all of these compounds in three or more solvent systems are given. The stability of the steroidal glucosiduronic acids in alkali, their hydrolysis by β-glucuronidase and their partition coefficients in several solvent systems are also given.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(71)90022-5