The effect of albumin concentration and storage time on the adhesion of washed porcine platelets to glass

The effect of storing platelet suspensions at room temperature before assessing platelet adhesiveness to glass was investigated. Changes found in adhesiveness depended on the albumin concentration of the suspension medium. The initial rate of platelet adhesion was inversely related to albumin concen...

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Bibliographic Details
Published inThrombosis research Vol. 23; no. 3; pp. 247 - 253
Main Authors Zingg, W, Hum, O.S, Absolom, D.R, Neumann, A.W
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.08.1981
Subjects
Albumin
Albumins - pharmacology
Animals
Cattle
Glass
Platelet adhesion
Platelet Adhesiveness
Platelet Aggregation
Platelet storage
Platelets
Preservation, Biological
Serum Albumin, Bovine - pharmacology
Swine
Albumin
Platelet storage
Platelet adhesion
Platelets
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Summary:The effect of storing platelet suspensions at room temperature before assessing platelet adhesiveness to glass was investigated. Changes found in adhesiveness depended on the albumin concentration of the suspension medium. The initial rate of platelet adhesion was inversely related to albumin concentration. Thereafter, during a 4-hr period, platelet adhesion decreased in suspensions with low (0–0.35%) albumin concentrations, whereas at higher concentrations, the adhesion was either not affected (1% albumin) or increased (2% albumin). These observations are explained by the different and opposite effects of albumin which adsorbs to glass more quickly than the platelets and improves the viability of the platelets during storage.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0049-3848
1879-2472
DOI:10.1016/0049-3848(81)90014-1