Kinetically directed combination therapy with adriamycin and X-irradiation in a mammary tumor model

• Published in: International journal of radiation oncology, biology, physics Vol. 7; no. 6; pp. 747 - 753
• Main Authors: Braunschweiger, Paul G, Schenken, Larry L, Schiffer, Lewis M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.1981
• Subjects: Adriamycin; Animals; Cell kinetics; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin - administration & dosage; Interphase; Kinetics; Male; Mammary Neoplasms, Experimental - therapy; Mammary tumors; Mice; Mice, Inbred DBA; Mitotic Index; Radiotherapy Dosage; X-irradiation; X-Rays; X-irradiation; Cell kinetics; Adriamycin; Mammary tumors

In the present studies, the interaction of adriamycin (A) and x-irradiation (X) in T1699 mouse mammary tumors was evaluated. Mitotic indices and thymidine labeling indices were determined at various intervals after A or X alone, and after A + X given in combination. The results with A (1.0 mg/kg) an...