Kinetically directed combination therapy with adriamycin and X-irradiation in a mammary tumor model

• Published in: International journal of radiation oncology, biology, physics Vol. 7; no. 6; pp. 747 - 753
• Main Authors: Braunschweiger, Paul G, Schenken, Larry L, Schiffer, Lewis M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.1981
• Subjects: Adriamycin; Animals; Cell kinetics; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin - administration & dosage; Interphase; Kinetics; Male; Mammary Neoplasms, Experimental - therapy; Mammary tumors; Mice; Mice, Inbred DBA; Mitotic Index; Radiotherapy Dosage; X-irradiation; X-Rays; X-irradiation; Cell kinetics; Adriamycin; Mammary tumors
• ISSN: 0360-3016; 1879-355X
• DOI: 10.1016/0360-3016(81)90468-5

In the present studies, the interaction of adriamycin (A) and x-irradiation (X) in T1699 mouse mammary tumors was evaluated. Mitotic indices and thymidine labeling indices were determined at various intervals after A or X alone, and after A + X given in combination. The results with A (1.0 mg/kg) and X (200 R) alone suggests that those quantities of each agent induce a G 2 progression delay of 9–12 brs. The kinetic results after A + X in combination indicated increased S phase transit. time and G 2 progression delay. Recovery kinetics after A + X were used to predict “optimmn” sequence intervals for subsequent A + X fractions. Sequential A + X treatment schedules, up to 4 fractions, were designed and evaluated by regrowth delay measurements. The results indicated that the interaction was additive when A and X were given together in combination. Fractionation of A + X to minimize proliferstive recovery between fractions resulted in an enhanced antitumor effect.