Molecular genetics of head and neck cancer (Review)

Understanding of molecular regulatory pathways presents a novel therapeutic approach for the treatment of head and neck cancer. These specific check points are becoming the targeted therapeutic approach. In this review, we highlight certain major signaling mechanisms, which are involved in the patho...

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Bibliographic Details
Published inMolecular medicine reports Vol. 6; no. 1; pp. 19 - 22
Main Authors Arora, Shitij, Aggarwal, Prachi, Pathak, Amit, Bhandari, Rekha, Duffoo, Frantz, Gulati, Subhash C
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications UK Ltd 01.07.2012
Subjects
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Cell growth
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Gene Expression Regulation, Neoplastic
Head & neck cancer
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - metabolism
Human papillomavirus
Humans
Insulin-like growth factors
Kinases
Mutation
Research - trends
Signal Transduction
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Summary:Understanding of molecular regulatory pathways presents a novel therapeutic approach for the treatment of head and neck cancer. These specific check points are becoming the targeted therapeutic approach. In this review, we highlight certain major signaling mechanisms, which are involved in the pathophysiology of head and neck cancer. Also, we discuss the current ongoing trials based on the in vitro success of targeted therapies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1791-2997
1791-3004
DOI:10.3892/mmr.2012.889