Understanding arsenic toxicity: Implications for environmental exposure and human health

Arsenic is a trace element and a metalloid which is prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from a wide array of industrial, chemical, residential, agricultural, and technological sources, leading to extensive pollution of water,...

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Bibliographic Details
Published inJournal of hazardous materials letters Vol. 5; p. 100090
Main Authors kaur, Ravidarshdeep, Garkal, Atul, Sarode, Lopmudra, Bangar, Priyanka, Mehta, Tejal, Singh, Dhirendra Pratap, Rawal, Rakesh
Format Journal Article
LanguageEnglish
Published Elsevier 01.11.2024
Subjects
Arsenic
Hazardous materials
Neurotoxicant
Toxic metals
Trace element
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Summary:Arsenic is a trace element and a metalloid which is prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from a wide array of industrial, chemical, residential, agricultural, and technological sources, leading to extensive pollution of water, soil, and air ecosystems including flora, fauna and humans. It poses significant harm to biological organisms upon acute and chronic exposure. In this review, we delve into the reported experimental data that elaborates on arsenic as a toxicant, with particular emphasis on its occurrence, metabolism and diverse molecular mechanisms involved. It also includes the major molecular mechanisms leading to systemic toxicity with special emphasis on shedding light on the intricate ways it disrupts the nervous system.
ISSN:2666-9110
2666-9110
DOI:10.1016/j.hazl.2023.100090