Intracerebroventricularly transplanted embryonic neuronal tissue from inflammatory-resistant F344/N rats decreases acoustic startle responses in inflammatory-susceptible LEW/N rats

Recently, we have shown that intracerebral transplantation of fetal F344/N hypothalamic tissue into LEW/N rats converts the LEW/N inflammatory-susceptible phenotype into an inflammatory-resistant phenotype in LEW/N hosts. Because LEW/N rats also exhibit relatively high acoustic startle responses (AS...

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Bibliographic Details
Published inCell transplantation Vol. 5; no. 2; p. 287
Main Authors Misiewicz, B, Poltorak, M, Gomez, M, Glowa, J R, Gold, P W, Sternberg, E M
Format Journal Article
LanguageEnglish
Published United States 01.03.1996
Subjects
Acoustic Stimulation
Animals
Behavior, Animal - physiology
Carrageenan - immunology
Female
Fetal Tissue Transplantation
Fetus - immunology
Hypothalamus
Immunohistochemistry
Inflammation - physiopathology
Injections, Intraventricular
Neurons - immunology
Neurons - transplantation
Rats
Rats, Inbred F344
Rats, Inbred Lew
Reflex, Startle - physiology
Stress, Physiological - physiopathology
Transplantation, Heterotopic
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Summary:Recently, we have shown that intracerebral transplantation of fetal F344/N hypothalamic tissue into LEW/N rats converts the LEW/N inflammatory-susceptible phenotype into an inflammatory-resistant phenotype in LEW/N hosts. Because LEW/N rats also exhibit relatively high acoustic startle responses (ASRs) compared to F344/N rats, in the present study we examined the effects on ASR of transplantation of F344/N hypothalamic tissue into the third ventricle of LEW/N rats. Dissected neuronal tissue from F344/N rats (Day E15-16) was implanted into the third ventricle of LEW/N rats. After 4 wk of postoperative survival, the animals' responses to acoustic startle stimuli were tested. Compared to naive and sham-operated animals, LEW/N rats transplanted with hypothalamic tissue exhibited significant decreases in ASR amplitudes. A similar decrease in ASR amplitude was observed in the group of LEW/N rats transplanted with embryonic striatal tissue. Our results indicate that the third ventricular neuronal grafts may modulate behavioral responses in the LEW/N rats. Although the mechanism of this effect is unknown, these studies suggest that intracerebral neuronal transplantation is a viable method with which to explore mechanisms of behavioral, neuroendocrine, and inflammatory response associations.
ISSN:0963-6897
1555-3892
DOI:10.1016/0963-6897(95)02027-6