Pro12Ala polymorphism in PPAR γ 2 associated with essential hypertension in Chinese nonagenarians/centenarians
The Pro12Ala polymorphism of PPAR γ 2 has been shown to influence hypertension and the benefit of longevity in previous studies. We examined whether the polymorphism was related to essential hypertension among long-lived subjects (≧90 years). The Pro12Ala variant was examined using polymerase chain...
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Published in | Experimental gerontology Vol. 43; no. 12; pp. 1108 - 1113 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Inc
01.12.2008
|
Subjects | |
Online Access | Get full text |
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Summary: | The Pro12Ala polymorphism of PPAR γ 2 has been shown to influence hypertension and the benefit of longevity in previous studies. We examined whether the polymorphism was related to essential hypertension among long-lived subjects (≧90 years). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism in a population-based sample of 839 long-lived subjects (mean 94 years SD 4 years, aged 90–108 years). The genotype frequencies of the Pro12Ala polymorphism were 0.2% Ala12Ala, 9.4% Pro12Ala and 90.4% Pro12Pro in all participants. The frequency of the Ala12 allele was 3.45% in the hypertension group and 6.92% among the normotension group (
P
=
0.001). Moreover, in the total study population, Ala12 allele carriers had lower levels of triglycerides (1.03
±
0.5
mmol/L (means
±
SD) vs. 1.25
±
0.61
mmol/L;
P
<
0.001). In conclusion, these results suggest that the Pro12Ala polymorphism of the PPAR γ 2 gene is associated with hypertension and triglycerides levels in Chinese nonagenarians/centenarians. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0531-5565 1873-6815 |
DOI: | 10.1016/j.exger.2008.08.046 |