Pro12Ala polymorphism in PPAR γ 2 associated with essential hypertension in Chinese nonagenarians/centenarians

• Published in: Experimental gerontology Vol. 43; no. 12; pp. 1108 - 1113
• Main Authors: Lu, Zhenchan, Dong, Birong, Mo, Xianming, Chen, Tie, Wu, Hongmei, Zhang, Yanling, Xiao, Hengyi
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.12.2008
• Subjects: Aged, 80 and over; Alleles; Asian Continental Ancestry Group; Blood Pressure - physiology; Body Mass Index; Elder; Female; Genotype; Humans; Hypertension; Hypertension - genetics; Male; Polymerase Chain Reaction; Polymorphism; Polymorphism, Restriction Fragment Length; PPAR gamma - genetics; PPAR γ 2; Risk Factors; Triglycerides; Triglycerides - genetics; Hypertension; Triglycerides; Elder; PPAR γ 2; Polymorphism
• ISSN: 0531-5565; 1873-6815
• DOI: 10.1016/j.exger.2008.08.046

The Pro12Ala polymorphism of PPAR γ 2 has been shown to influence hypertension and the benefit of longevity in previous studies. We examined whether the polymorphism was related to essential hypertension among long-lived subjects (≧90 years). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism in a population-based sample of 839 long-lived subjects (mean 94 years SD 4 years, aged 90–108 years). The genotype frequencies of the Pro12Ala polymorphism were 0.2% Ala12Ala, 9.4% Pro12Ala and 90.4% Pro12Pro in all participants. The frequency of the Ala12 allele was 3.45% in the hypertension group and 6.92% among the normotension group ( P = 0.001). Moreover, in the total study population, Ala12 allele carriers had lower levels of triglycerides (1.03 ± 0.5 mmol/L (means ± SD) vs. 1.25 ± 0.61 mmol/L; P < 0.001). In conclusion, these results suggest that the Pro12Ala polymorphism of the PPAR γ 2 gene is associated with hypertension and triglycerides levels in Chinese nonagenarians/centenarians.