Role of endogenous cyclo(His-Pro) in cold-induced hypothermia in the desert rat ( Mastomys natalensis)

• Published in: Peptides (New York, N.Y. : 1980) Vol. 15; no. 8; pp. 1471 - 1474
• Main Authors: Shukla, Rakesh, Rahmani, N.H., Mizuma, Haruo, Srimal, Rikhab Chand, Prasad, Chandan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 1994
• Subjects: Analysis of Variance; Animals; Antibodies - administration & dosage; Antibodies - pharmacology; Body Temperature - drug effects; Body Temperature Regulation; Cerebral Ventricles - drug effects; Cerebral Ventricles - physiology; Cold Temperature; Cold-induced hypothermia; Cyclo(Ala-Gly); Cyclo(His-Pro); Desert Climate; Diketopiperazines; Endogenous cyclo(His-Pro); Hypothalamus - drug effects; Hypothalamus - physiology; Hypothermia; Hypothermia, Induced; Injections, Intraventricular; Male; Mastomys natalensis; Muridae - physiology; Peptides, Cyclic - administration & dosage; Peptides, Cyclic - analysis; Peptides, Cyclic - antagonists & inhibitors; Peptides, Cyclic - pharmacology; Peptides, Cyclic - physiology; Piperazines - administration & dosage; Piperazines - analysis; Piperazines - antagonists & inhibitors; Piperazines - pharmacology; Rats; Species Specificity; Thermoregulation; Cyclo(Ala-Gly); Endogenous cyclo(His-Pro); Thermoregulation; Cold-induced hypothermia; Mastomys natalensis; Cyclo(His-Pro); Hypothermia
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/0196-9781(94)90125-2

Central administration of exogenous cyclo(His-Pro) (CHP) is known to produce hypothermia in rodents. In the present study, we examined the role of endogenous CHP in cold-induced hypothermia in the desert rat, Mastomys natalensis. The results of these studies show that a rise in hypothalamic CHP content accompanied a decrease in rectal temperature during cold exposure. Immunoneutralization of endogenous CHP resulted in a significant decline in cold-induced hypothermia. In addition, central administration of cyclo(Ala-Gly), a structural analogue of CHP, also led to a decrease in cold-induced hypothermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation.