Stabilization of heterogeneous nuclear RNA by intercalating drugs
The effect of the intercalating drugs proflavine, ethidium and daunomycin on the rate of degradation of 14C-labeled heterogeneous nuclear RNA (HnRNA) in KB cells was studied. All three drugs decreased the rate of degradation of 14C-HnRNA to acid soluble products. The most striking effect was produce...
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| Published in | Biochemical and biophysical research communications Vol. 52; no. 3; pp. 928 - 934 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
08.06.1973
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| Subjects | |
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| Abstract | The effect of the intercalating drugs proflavine, ethidium and daunomycin on the rate of degradation of
14C-labeled heterogeneous nuclear RNA (HnRNA) in KB cells was studied. All three drugs decreased the rate of degradation of
14C-HnRNA to acid soluble products. The most striking effect was produced by proflavine which promptly and completely stabilized
14C-HnRNA against degradation. Ethidium also produced complete stabilization after a delay of 30 to 60 min. Daunomycin decreased the rate of
14C-HnRNA degradation but did not alter the fraction of
14C-HnRNA which was ultimately degraded. The results are consistent with the view that base-paired sequences are present in HnRNA
in vivo
and play a role in the processing of HnRNA. |
|---|---|
| AbstractList | The effect of the intercalating drugs proflavine, ethidium and daunomycin on the rate of degradation of
14C-labeled heterogeneous nuclear RNA (HnRNA) in KB cells was studied. All three drugs decreased the rate of degradation of
14C-HnRNA to acid soluble products. The most striking effect was produced by proflavine which promptly and completely stabilized
14C-HnRNA against degradation. Ethidium also produced complete stabilization after a delay of 30 to 60 min. Daunomycin decreased the rate of
14C-HnRNA degradation but did not alter the fraction of
14C-HnRNA which was ultimately degraded. The results are consistent with the view that base-paired sequences are present in HnRNA
in vivo
and play a role in the processing of HnRNA. |
| Author | Brinker, Jane M. Bello, Leonard J. Madore, H.Paul |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4710572$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1128/MMBR.32.3.262-290.1968 10.1016/0005-2787(68)90368-7 10.1016/S0022-2836(66)80009-8 10.1016/S0021-9258(18)95813-8 10.1128/JVI.1.5.843-850.1967 10.1016/S0021-9258(18)95814-X 10.1016/0022-2836(68)90234-9 10.1083/jcb.41.1.177 10.1016/0022-2836(69)90104-1 10.1016/0022-2836(67)90353-1 10.1016/0005-2787(72)90502-3 10.1016/S0014-4827(63)80003-8 10.1002/jcp.1030640403 10.1021/bi00865a031 10.1038/newbio236172a0 10.1038/239143a0 10.1016/S0022-2836(66)80010-4 10.1083/jcb.39.1.112 10.1016/0022-2836(69)90420-3 10.1016/0022-2836(71)90371-8 10.1016/0005-2787(67)90116-5 10.1038/2191320a0 10.1021/bi00726a006 |
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| SubjectTerms | Acridines - pharmacology Amines - pharmacology Binding Sites Carbon Isotopes Carcinoma Cell Line Cycloheximide - pharmacology Dactinomycin - pharmacology Daunorubicin - pharmacology Drug Stability Ethidium - pharmacology Humans Kinetics Mouth Neoplasms Nucleic Acid Conformation Nucleic Acid Denaturation Phenanthridines - pharmacology RNA, Neoplasm - metabolism |
| Title | Stabilization of heterogeneous nuclear RNA by intercalating drugs |
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