Formation of 1,3-Dihydroxy-N-methylacridone from N-Methylanthraniloyl-CoA and Malonyl-CoA by Cell-Free Extracts of Ruta graveolens
N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-m...
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| Published in | Zeitschrift für Naturforschung C. A journal of biosciences Vol. 47; no. 5; pp. 365 - 368 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tübingen
Verlag der Zeitschrift für Naturforschung
01.06.1992
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| Subjects | |
| Online Access | Get full text |
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| Abstract | N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-methylacridone from N-methylanthraniloyl-CoA and malonyl-CoA with a pH optimum of 7.5. |
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| AbstractList | N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-methylacridone from N-methylanthraniloyl-CoA and malonyl-CoA with a pH optimum of 7.5. |
| Author | Porzel, Andrea Baumert, Alfred Schmidt, Jürgen Gröger, Detlef |
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| Keywords | Enzymatic synthesis Alkaloid Nitrogen heterocycle Dicotyledones Biotransformation Angiospermae Rutaceae Spermatophyta Aromatic compound Tricyclic compound Cell free system |
| Language | English |
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| Snippet | N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was... |
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| SubjectTerms | Acridone Biosynthesis Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Cell-Free System Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies N-Methylanthraniloyl-CoA Ruta graveolens |
| Title | Formation of 1,3-Dihydroxy-N-methylacridone from N-Methylanthraniloyl-CoA and Malonyl-CoA by Cell-Free Extracts of Ruta graveolens |
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