Formation of 1,3-Dihydroxy-N-methylacridone from N-Methylanthraniloyl-CoA and Malonyl-CoA by Cell-Free Extracts of Ruta graveolens

N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-m...

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Published inZeitschrift für Naturforschung C. A journal of biosciences Vol. 47; no. 5; pp. 365 - 368
Main Authors Baumert, Alfred, Porzel, Andrea, Schmidt, Jürgen, Gröger, Detlef
Format Journal Article
LanguageEnglish
Published Tübingen Verlag der Zeitschrift für Naturforschung 01.06.1992
Subjects
Acridone Biosynthesis
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Cell-Free System
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
N-Methylanthraniloyl-CoA
Ruta graveolens
Enzymatic synthesis
Alkaloid
Nitrogen heterocycle
Dicotyledones
Biotransformation
Angiospermae
Rutaceae
Spermatophyta
Aromatic compound
Tricyclic compound
Cell free system
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Summary:N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-methylacridone from N-methylanthraniloyl-CoA and malonyl-CoA with a pH optimum of 7.5.
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-1992-0608