Production of arachidonic acid metabolites by operationally defined macrophage subsets

The antitumor activity and arachidonic acid metabolism of operationally defined macrophage populations was examined. Macrophages from mice injected with Mycobacterium bovis (strain BCG) or with pyran-copolymer were cytotoxic for tumor cells. The major arachidonic acid metabolite of these cells was P...

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Published inProstaglandins Vol. 25; no. 4; pp. 491 - 501
Main Authors Snider, Mary Ellen, Fertel, Richard H., Zwilling, Bruce S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1983
Subjects
Animals
Arachidonic Acid
Arachidonic Acids - metabolism
Cytotoxicity, Immunologic
DNA Replication
L Cells (Cell Line) - immunology
Macrophage Activation
Macrophages - immunology
Macrophages - metabolism
Male
Mice
Mice, Inbred BALB C
Mycobacterium bovis - immunology
Prostaglandins - biosynthesis
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Summary:The antitumor activity and arachidonic acid metabolism of operationally defined macrophage populations was examined. Macrophages from mice injected with Mycobacterium bovis (strain BCG) or with pyran-copolymer were cytotoxic for tumor cells. The major arachidonic acid metabolite of these cells was PGE 2. Neither resident nor elicited macrophages were cytotoxic. However, elicited macrophages as well as macrophages from BCG injected mice inhibited tumor cell growth. The production of arachidonic acid metabolites by elicited cells, while low initially, was followed by a rapid increase in PGE 2. The major metabolites of resident cells were PGE 2 and prostacyclin. The cAMP:cGMP ratio correlated with the metabolic activity of the cells.
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ISSN:0090-6980
DOI:10.1016/0090-6980(83)90021-7