Severe Acute Respiratory Syndrome Coronavirus 2 Adaptive Immunity in Nursing Home Residents Following a Third Dose of the Comirnaty Coronavirus Disease 2019 Vaccine

Abstract A third Comirnaty vaccine dose increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain antibody levels (median, 93-fold) and neutralizing antibody titers against Wuhan-Hu-1 (median, 57-fold), Beta (me 22-fold), Delta, (median, 43-fold), and Omicron (me...

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Published inClinical infectious diseases Vol. 75; no. 1; pp. e865 - e868
Main Authors Giménez, Estela, Albert, Eliseo, Zulaica, Joao, Torres, Ignacio, Rusu, Luciana, Moreno, Alicia Rodríguez, Burgos, Javier S, Peiró, Salvador, Salas, Dolores, Vanaclocha, Hermelinda, Limón, Ramón, Alcaraz, María Jesús, Sánchez-Payá, José, Díez-Domingo, Javier, Comas, Iñaki, Gonzáles-Candelas, Fernando, Geller, Ron, Navarro, David
Format Journal Article
LanguageEnglish
Published US Oxford University Press 24.08.2022
Subjects
Adaptive Immunity
Antibodies, Neutralizing
Antibodies, Viral
COVID-19 - prevention & control
COVID-19 Vaccines
Humans
Neutralization Tests
Nursing Homes
SARS-CoV-2
Viral Vaccines
Comirnaty COVID-19 vaccine third dose
SARS-CoV-2-S antibodies
SARS-CoV-2-S T cells
neutralizing antibodies
nursing home residents
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Summary:Abstract A third Comirnaty vaccine dose increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain antibody levels (median, 93-fold) and neutralizing antibody titers against Wuhan-Hu-1 (median, 57-fold), Beta (me 22-fold), Delta, (median, 43-fold), and Omicron (median, 8-fold) variants, but had less impact on S-reactive T-cell immunity in nursing home residents.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac223