Tissue factor: then and now

Much has been learned about tissue factor during the past 25 years and much is yet to be learned. On the biochemical level, the association of TF:VIIa with factor X is yet to be resolved. The mechanism by which TF is transported from the nucleus to the plasma membrane has yet to even be approached....

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 74; no. 1; p. 180
Main Author Nemerson, Y
Format Journal Article
LanguageEnglish
Published Germany 01.07.1995
Subjects
Arteriosclerosis - metabolism
Cells, Cultured
Factor VIIa - metabolism
Factor X - metabolism
Humans
Kinetics
Macromolecular Substances
Membrane Lipids - physiology
Phospholipids - physiology
Protein Binding
Thromboplastin - isolation & purification
Thromboplastin - physiology
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Summary:Much has been learned about tissue factor during the past 25 years and much is yet to be learned. On the biochemical level, the association of TF:VIIa with factor X is yet to be resolved. The mechanism by which TF is transported from the nucleus to the plasma membrane has yet to even be approached. Thus, those of us studying this interesting and fundamentally important molecule have much work in the future.
ISSN:0340-6245
DOI:10.1055/s-0038-1642673