The influence of intraperitoneal injections of histamine on tumour growth in fibrosarcoma-bearing mice

Twenty C57BL 6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL 6 mice, tumour growth was significantly slower than in control...

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Bibliographic Details
Published inCancer letters Vol. 12; no. 3; pp. 195 - 201
Main Authors Burtin, C., Scheinmann, P., Salomon, J.C., Lespinats, G., Loisillier, F., Canu, P.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.04.1981
Subjects
Animals
Female
Fibrosarcoma - chemically induced
Fibrosarcoma - drug therapy
Histamine - administration & dosage
Histamine - pharmacology
Injections, Intraperitoneal
Male
Methylcholanthrene
Mice
Neoplasm Transplantation
Sarcoma, Experimental - chemically induced
Sarcoma, Experimental - drug therapy
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Summary:Twenty C57BL 6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL 6 mice, tumour growth was significantly slower than in control mice until day 18. Thereafter, the tumour growth rate of treated compared to control mice was accelerated. In 10 out of 20 C3H mice, tumour growth was significantly slower until day 25; in histamine responsive C3H mice, histological studies showed numerous and large loci of acute haemorrhagic necrosis in the tumours.
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(81)90068-9