Comparison of single-dose antithrombotic agents in the prevention of microvascular thrombosis

A model of thrombosis was used to evaluate the efficacy of single-dose heparin, hemodilution, and 40,000 milliwatts dextran in the prevention of microvascular thrombosis. Forty Lewis rats (275 gm body weight) were divided into four groups (n = 10): hemodilution (6 ml NS), single-dose heparin (1 mu/g...

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Bibliographic Details
Published inThe Journal of hand surgery (American ed.) Vol. 16; no. 4; p. 585
Main Authors Davidson, S F, Brantley, S K, Das, S K
Format Journal Article
LanguageEnglish
Published United States 01.07.1991
Subjects
Animals
Blood Coagulation - drug effects
Dextrans - administration & dosage
Drug Administration Schedule
Femoral Artery - ultrastructure
Hemodilution
Heparin - administration & dosage
Heparin - therapeutic use
Microcirculation
Rats
Rats, Inbred Lew
Sodium Chloride - administration & dosage
Thrombosis - blood
Thrombosis - pathology
Thrombosis - prevention & control
Vascular Patency
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Summary:A model of thrombosis was used to evaluate the efficacy of single-dose heparin, hemodilution, and 40,000 milliwatts dextran in the prevention of microvascular thrombosis. Forty Lewis rats (275 gm body weight) were divided into four groups (n = 10): hemodilution (6 ml NS), single-dose heparin (1 mu/gm), 40,000 mw dextran (0.3 gm/100 gm), and control (0.275 ml NS). After exposure of the superficial femoral arteries, a model of arterial crush with arteriotomy followed by an intimal abrasion was used. The animals randomly received one of the four solutions above. Experimental results included patency rates of 90% at 20 minutes and 10% at 24 hours in the hemodilution group, 100% at 20 minutes, and 70% at 24 hours in the single-dose heparin group, and 100% at both 20 minutes and 24 hours in the dextran group. A 100% thrombosis rate was observed in the control group at 20 minutes and 24 hours. Single-dose heparin and dextran significantly improved patency in comparison to both the control and hemodilution groups at 24 hours (p less than 0.01). Scanning electron microscopy of the vessels revealed thrombus deposition consistent with these findings. These results indicate that single-dose heparin and single-dose dextran reduce thrombosis in this model of microvascular injury.
ISSN:0363-5023
DOI:10.1016/0363-5023(91)90177-D