The joint toxic action of perchloroethylene with benzene or toluene in rats

The joint toxic action of mixtures of perchloroethylene with benzene or toluene was tested at five dose levels for each of six binary combinations with 20 rats per dose. LD50 data with 95% fiducial limits are reported for each mixture and tests for additive joint toxicity were made. The results indi...

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Bibliographic Details
Published inToxicology (Amsterdam) Vol. 4; no. 1; p. 5
Main Authors Withey, R J, Hall, J W
Format Journal Article
LanguageEnglish
Published Ireland 1975
Subjects
Animals
Benzene - toxicity
Drug Interactions
Lethal Dose 50
Male
Models, Biological
Rats
Tetrachloroethylene - toxicity
Toluene - toxicity
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Summary:The joint toxic action of mixtures of perchloroethylene with benzene or toluene was tested at five dose levels for each of six binary combinations with 20 rats per dose. LD50 data with 95% fiducial limits are reported for each mixture and tests for additive joint toxicity were made. The results indicate that the mixtures of perchloroethylene and benzene gave values for the LD50 which were slightly less than additive while perchloroethylene and toluene mixtures had LD50 values which could not be predicted by an additive model.
ISSN:0300-483X
DOI:10.1016/0300-483X(75)90017-7