Newer substituted beta-aminonaphthalenes as potent anti-inflammatory agents

• Published in: Arzneimittel-Forschung Vol. 50; no. 11; pp. 1009 - 1014
• Main Authors: Bansal, E, Srivastava, VK, Kumar, A
• Format: Journal Article
• Language: English
• Published: AULENDORF Ecv-Editio Cantor Verlag Medizin Naturwissenschaften 01.11.2000
• Subjects: 2-Naphthylamine - analogs & derivatives; 2-Naphthylamine - chemical synthesis; 2-Naphthylamine - pharmacology; 2-Naphthylamine - toxicity; Analgesics, Non-Narcotic - chemical synthesis; Analgesics, Non-Narcotic - pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - toxicity; Benzoquinones; Carrageenan; Chemical Phenomena; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Chemistry, Physical; Edema - chemically induced; Edema - prevention & control; Female; Lethal Dose 50; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Male; Mice; Pain Measurement - drug effects; Pharmacology & Pharmacy; Physical Sciences; Rats; Science & Technology; Stomach Ulcer - chemically induced; acute toxicity studies, anti-inflammatory and analgesic activity, rat, synthesis; formazanyl-thiazolyl aminonaphthalenes; and analgesic activity, rat, synthesis; acute toxicity studies, anti-inflammatory; azetidinyl-thiazolylaminonaphthalenes
• ISSN: 0004-4172
• DOI: 10.1055/s-0031-1300325

beta-[2-(3'-Chloro-2'-oxo-4'-substituted aryl-1'-azetidinyl)-thiazol-4-yl] aminonaphthalenes 13-17 and beta-[2-(1',3'-disubstitutedphenyl-formazan-4'-yl) aminonaphthalenes 8-12 were synthesized from beta-(2-arylideneamino-thiazol-4-yl)aminonaphthalenes 3-7 by diazotisation and by cycloaddition with monochloroacetyl chloride, respectively, on the azomethine group of the compounds 3-7. The newly synthesized compounds showed potent anti-inflammatory and analgesic activities and were less ulcerogenic than phenylbutazone.