Effect of exogenous ubiquinone-10 on the ubiquinone pool of liver and spleen of mice

• Published in: Biochimica et biophysica acta Vol. 362; no. 2; pp. 326 - 331
• Main Authors: Bliznakov, Emile G., Casey, Adria C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.09.1974
• Subjects: Animals; Carbon Radioisotopes; Emulsions; Liver - drug effects; Liver - metabolism; Male; Mice; Mice, Inbred Strains; Organ Specificity; Polysorbates; Spleen - drug effects; Spleen - metabolism; Time Factors; Ubiquinone - metabolism; Ubiquinone - pharmacology
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/0304-4165(74)90225-6

The ubiquinone content in liver and spleen of mice after single intravenous administration of 150 μg/mouse ubiquinone-10 emulsion was investigated. It was found that 1 day after this administration, there is significant increase in the total ubiquinone concentration in the liver and the spleen, which returns to control level 7 days later. Moreover, 15 days after the administration there is a second marked increase in the total ubiquinone concentration in both organs. This second increase occurs long after the exogenous ubiquinone-10 has been completely metabolized. It has been demonstrated by others that exogenous ubiquinones are almost completely metabolized and excreted 72 h after administration. Although the origin of the second concentration increase cannot be explained at present, an increase in the rate of the endogenous ubiquinone biosynthesis resulting from distortion of the biosynthetic feedback mechanism produced by the exogenous ubiquinone-10 may be one likely possibility.