Phosphorylation of 5-LOX: The Potential Set-point of Inflammation

• Published in: Neurochemical research Vol. 45; no. 10; pp. 2245 - 2257
• Main Authors: He, Zonglin, Tao, Di, Xiong, Jiaming, Lou, Fangfang, Zhang, Jiayuan, Chen, Jinxia, Dai, Weixi, Sun, Jing, Wang, Yuechun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2020
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Neurochemistry; Neurology; Neurosciences; Review; Arachidonate; Phosphorylation; Inflammation; Leukotrienes; 5-Lipoxygenase

Inflammation secondary to tissue injuries serves as a double-edged sword that determines the prognosis of tissue repair. As one of the most important enzymes controlling the inflammation process by producing leukotrienes, 5-lipoxygenase (5-LOX, also called 5-LO) has been one of the therapeutic targe...