A role for glucocorticoids in the polyphosphoinositide second messenger system

• Published in: Medical hypotheses Vol. 22; no. 3; pp. 309 - 319
• Main Author: Sorenson, Dean
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.03.1987
• Subjects: Calcium - metabolism; Cell Membrane - drug effects; Cell Membrane - metabolism; Dinoprostone; Glucocorticoids - physiology; Glucose - metabolism; Humans; Lymphocyte Activation - drug effects; Lymphokines - metabolism; Phosphatidylinositol Phosphates; Phosphatidylinositols - metabolism; Prostaglandins E - metabolism; Protein Kinase C - metabolism; RNA, Messenger - drug effects; T-Lymphocytes - drug effects; T-Lymphocytes - enzymology; T-Lymphocytes - metabolism; Transcription, Genetic
• ISSN: 0306-9877; 1532-2777
• DOI: 10.1016/0306-9877(87)90196-4

Glucocorticoids have been shown to be involved in numerous secretory and activation processes which are known to be mediated by the polyphosphoinositide second messenger system. A connection between glucocorticoids and the polyphosphoinositide system has not been made because of the marked temporal differences in their effects and the fact that most of the known effects of glucocorticoids involve transcription and/or protein synthesis. An attempt is made to to rationalize these apparant incongruities. The recently reported stimulation of glucose transport by kinase C suggests an experimental system to investigate glucocorticoid effects on the polyphosphoinositide system.