Cell therapy of cerebral palsy

• Published in: Bulletin of experimental biology and medicine Vol. 139; no. 4; pp. 499 - 503
• Main Authors: Seledtsov, V I, Kafanova, M Yu, Rabinovich, S S, Poveshchenko, O V, Kashchenko, E A, Fel'de, M A, Samarin, D M, Seledtsova, G V, Kozlov, V A
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.04.2005
• Subjects: Case-Control Studies; Cell- and Tissue-Based Therapy; Cerebral Palsy - pathology; Cerebral Palsy - therapy; Child, Preschool; Female; Humans; Male
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-005-0330-2

The paper presents the results of a controlled study of cell therapy in 30 patients with severe forms of cerebral palsy. A cell suspension from immature nervous and hemopoietic tissues was injected into the subarachnoidal space of a recipient through a spinal puncture. Immune sensitization to donor antigens (detected by suppression of lymphocyte migration) was noted in few patients. In none patients laboratory and clinical signs of tissue-destructive autoimmune reactions were observed. One year after treatment activity of the major psychomotor functions in treated patients considerably surpassed the normal. No delayed complications of cell therapy were noted. These findings suggest that cell therapy is an effective, safe, and immunologically justified method of therapy for patients with cerebral palsy.