Changes in factor VIII proteins after cardiopulmonary bypass in man suggest endothelial damage

16 patients undergoing coronary artery bypass grafting using cardiopulmonary bypass (CPB) had blood samples taken at various times before, during and up to 1 week after surgery for estimation of beta-thromboglobulin (BTG), alpha-1-antichymotrypsin (ACT), factor VIII procoagulant protein (VIII:C), vo...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 60; no. 2; p. 199
Main Authors Jones, D K, Luddington, R, Higenbottam, T W, Scott, J, Cavarocchi, N, Reardon, D, Calvin, J, Wallwork, J
Format Journal Article
LanguageEnglish
Published Germany 31.10.1988
Subjects
Adult
Aged
alpha 1-Antichymotrypsin - metabolism
Antigens - metabolism
beta-Thromboglobulin - metabolism
Cardiopulmonary Bypass - adverse effects
Endothelium, Vascular - metabolism
Epoprostenol - pharmacology
Factor VIII - metabolism
Female
Humans
Male
Middle Aged
Platelet Count
von Willebrand Factor - immunology
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Summary:16 patients undergoing coronary artery bypass grafting using cardiopulmonary bypass (CPB) had blood samples taken at various times before, during and up to 1 week after surgery for estimation of beta-thromboglobulin (BTG), alpha-1-antichymotrypsin (ACT), factor VIII procoagulant protein (VIII:C), von Willebrand factor antigen (vWF:Ag) and ristocetin co-factor (vWF:RiCoF). vWF:Ag and vWF:RiCoF rose during and following surgery in a different manner to ACT. At 1 week there was a significantly disproportionate rise in vWF:Ag compared to vWF:RiCoF which suggested a degree of pulmonary endothelial damage. Prostacyclin, which was administered to 8 of the patients during CPB, reduced platelet activation as measured by a reduction in the release of BTG and also attenuated the consumption of VIII:C. It had no effect on pulmonary endothelial damage as measured by the ratio of vWF:Ag to vWF:RiCoF.
ISSN:0340-6245
DOI:10.1055/s-0038-1647029