Dihydrotestosterone activates male mating behavior in castrated King—Holtzman rats

Having previously found that King-Holtzman rats respond behaviorally to dihydrotestosterone (DHT), this strain was used to compare the effectiveness of DHT and dihydrotestosterone propionate (DHTP) in maintaining and reinstating copulatory behavior. The 5α-reduced androgens were capable of stimulati...

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Bibliographic Details
Published inHormones and behavior Vol. 18; no. 4; pp. 380 - 392
Main Authors Olsen, K.L., Whalen, R.E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.1984
Subjects
Adrenal Cortex - secretion
Animals
Castration
Copulation - drug effects
Dihydrotestosterone - analogs & derivatives
Dihydrotestosterone - pharmacology
Ejaculation - drug effects
Guinea Pigs
Male
Rats
Rats, Inbred Strains
Species Specificity
Stimulation, Chemical
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Summary:Having previously found that King-Holtzman rats respond behaviorally to dihydrotestosterone (DHT), this strain was used to compare the effectiveness of DHT and dihydrotestosterone propionate (DHTP) in maintaining and reinstating copulatory behavior. The 5α-reduced androgens were capable of stimulating mating behavior in these castrated male rats. DHT and DHTP were equally effective in maintaining ejaculatory behavior, whereas DHT was slightly more potent behaviorally than DHTP in restoring mating responses. It was found that as little as 200 μg hormone/day restored ejaculatory behavior in 78% of the DHT-treated and 50% of the DHTP-treated rats. In both the maintenance and restoration paradigms, the mating performance of the DHT(P) treated males declined over time. The present data suggest that the conversion of androgen to estrogen may not be critical for the activation of male mating behavior.
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ISSN:0018-506X
1095-6867
DOI:10.1016/0018-506X(84)90024-2