The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats

Rats were given single or repeated injection of desmethylimipramine (DMI) and subjected to a single session of restraint or footshock stress. The degree of anorexia and plasma corticosterone elevation in response to the stress was measured. Repeated but not single injection of DMI was found to reduc...

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Bibliographic Details
Published inProgress in neuro-psychopharmacology & biological psychiatry Vol. 8; no. 4-6; p. 587
Main Authors Stone, E A, Trullas, R, Platt, J E
Format Journal Article
LanguageEnglish
Published England 1984
Subjects
Acute Disease
Animals
Anorexia - prevention & control
Chronic Disease
Corticosterone - blood
Depression - drug therapy
Desipramine - therapeutic use
Electroshock
Feeding and Eating Disorders - prevention & control
Humans
Male
Rats
Rats, Inbred Strains
Restraint, Physical
Stress, Physiological - complications
Stress, Physiological - drug therapy
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Summary:Rats were given single or repeated injection of desmethylimipramine (DMI) and subjected to a single session of restraint or footshock stress. The degree of anorexia and plasma corticosterone elevation in response to the stress was measured. Repeated but not single injection of DMI was found to reduce the anorectic response to restraint and footshock but not to affect the corticosterone response to restraint. It is concluded that repeated DMI treatment has differential effects on responses to acute stress.
ISSN:0278-5846
DOI:10.1016/0278-5846(84)90019-8