MRI Radiomics Analysis for Predicting the Pathologic Classification and TNM Staging of Thymic Epithelial Tumors: A Pilot Study

• Published in: American journal of roentgenology (1976) Vol. 214; no. 2; pp. 328 - 340
• Main Authors: Xiao, Gang, Rong, Wei-Cheng, Hu, Yu-Chuan, Shi, Zhong-Qiang, Yang, Yang, Ren, Jia-Liang, Cui, Guang-Bin
• Format: Journal Article
• Language: English
• Published: United States 01.02.2020
• Subjects: Female; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Neoplasm Staging; Neoplasms, Glandular and Epithelial - diagnostic imaging; Neoplasms, Glandular and Epithelial - pathology; Nomograms; Pilot Projects; Predictive Value of Tests; Retrospective Studies; Support Vector Machine; Thymus Neoplasms - diagnostic imaging; Thymus Neoplasms - pathology; thymic epithelial tumors; radiomics; TNM staging; nomogram; pathologic classification
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/ajr.19.21696

The purpose of this study was to explore the performance of MRI radiomics in predicting the pathologic classification and TNM staging of thymic epithelial tumors (TETs). Clinical and MRI data for 189 patients with TETs were retrospectively collected. A total of 2088 radiomics features were extracted from T2-weighted images and T2-weighted fat-suppressed (FS) images. With the use of a support vector machine with recursive feature elimination, the optimal feature subsets were selected and used to construct two predictive models for pathologic classification and TNM staging. In multivariable logistic regression analysis, we incorporated the radiomics model, conventional MRI findings, and clinical variables to develop a radiomics nomogram for predicting risk stratification of advanced TETs. Of the extracted features, 125 features were selected to construct the radiomics model for predicting pathologic classification, and 69 features were selected to construct the radiomics model for predicting TNM staging. The models achieved AUC values of 0.880 and 0.948 in the training cohort and 0.771 and 0.908 in the test cohort, respectively, for distinguishing among low-risk thymomas, high-risk thymomas, and thymic carcinomas and differentiating between early-stage and advanced-stage TETs. The radiomics model, symptom, and pericardial effusion constituted a radiomics nomogram, with an AUC value of 0.967 (95% CI, 0.891-0.989) in the training cohort and 0.957 (95% CI, 0.842-0.974) in the test cohort. MRI radiomics analysis has the potential to differentiate the pathologic classification and TNM staging of TETs. A radiomics nomogram provides a useful tool for in dividualized prediction of the risk of advanced-stage TET before a patient undergoes treatment.