An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development

Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups. In this issue of Developmental Cell, Patmore et al. identify Ddx3x as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that restricts cell...

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Bibliographic Details
Published inDevelopmental cell Vol. 54; no. 4; pp. 425 - 426
Main Authors Hwang, Grace H., Segal, Rosalind A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 24.08.2020
Subjects
Carcinogenesis
Cerebellar Neoplasms
DEAD-box RNA Helicases - genetics
DEAD-box RNA Helicases - metabolism
Humans
Medulloblastoma - genetics
Mutation
Rhombencephalon - metabolism
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Summary:Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups. In this issue of Developmental Cell, Patmore et al. identify Ddx3x as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that restricts cell lineage progression in tumorigenesis. Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subtypes. In this issue of Developmental Cell, Patmore et al. identify Ddx3x as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that restricts cell lineage progression in tumorigenesis.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2020.07.021