Catalase activity in human hepatocellular carcinoma (HCC)

Liver catalase activity, one of the free-radical scavenger enzymes, has been measured in 22 normal subjects and compared with that of 13 patients suffering from hepatocellular carcinoma. The activity was estimated both in tumor tissue and in tumor-free tissue. A significant reduction of catalase act...

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Bibliographic Details
Published inClinical biochemistry Vol. 20; no. 6; pp. 415 - 417
Main Authors Bellisola, G., Casaril, M., Gabrielli, G.B., Caraffi, M., Corrocher, R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.1987
Subjects
Adult
Aged
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - enzymology
catalase
Catalase - blood
Catalase - metabolism
Female
free radicals
hepatoma
Humans
Iron - blood
liver
Liver - enzymology
Liver Cirrhosis - complications
Liver Cirrhosis - enzymology
Liver Neoplasms - complications
Liver Neoplasms - enzymology
Male
Middle Aged
free radicals
liver
hepatoma
catalase
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Summary:Liver catalase activity, one of the free-radical scavenger enzymes, has been measured in 22 normal subjects and compared with that of 13 patients suffering from hepatocellular carcinoma. The activity was estimated both in tumor tissue and in tumor-free tissue. A significant reduction of catalase activity was noted in tumor tissue ( p < 0.001) as well as in the adjacent tumor-free tissue ( p < 0.02). In patients with hepatoma, the serum iron level was lower than in normal ( p < 0.01) and was correlated with enzyme activity ( r = 0.958). These findings suggest that in hepatocarcinoma the free radical scavenger system is impaired.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-9120
1873-2933
DOI:10.1016/0009-9120(87)90007-5