Hypogammaglobulinemia and hypoalbuminemia in neonates with ruptured omphaloceles and gastroschisis

Infants born with ruptured omphaloceles have significantly decreased levels of total serum proteins, albumin, immunoglobulin G, and transferrin. The most likely explanation of these findings is the loss of serum into amniotic fluid from the peritoneal surfaces of the exposed viscera. The data indica...

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Bibliographic Details
Published inJournal of pediatric surgery Vol. 8; no. 3; pp. 353 - 359
Main Authors Gutenberger, James E., Miller, D.Lee, Dibbins, Albert W., Gitlin, David
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.1973
Subjects
Abdominal Muscles - abnormalities
Agammaglobulinemia - etiology
Age Factors
Albumins - therapeutic use
Autopsy
Birth Weight
Blood
Blood Proteins - analysis
Child
Child, Preschool
Follow-Up Studies
Gestational Age
Hernia, Umbilical - blood
Hernia, Umbilical - complications
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infant
Infant, Newborn
Lymphoid Tissue - pathology
Rupture, Spontaneous - complications
Rupture, Spontaneous - congenital
Rupture, Spontaneous - drug therapy
Serum Albumin - analysis
Transferrin - analysis
Umbilical Cord
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Summary:Infants born with ruptured omphaloceles have significantly decreased levels of total serum proteins, albumin, immunoglobulin G, and transferrin. The most likely explanation of these findings is the loss of serum into amniotic fluid from the peritoneal surfaces of the exposed viscera. The data indicate that infants with ruptured omphaloceles require immediate serum protein assessment at birth to determine the need for albumin to improve tissue perfusion and gamma globulin to lessen the risks of sepsis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3468
1531-5037
DOI:10.1016/0022-3468(73)90102-4