Release of pancreatic secretory trypsin inhibitor from human hepatoblastoma cells on stimulation with cytokines

To determine whether or not human pancreatic secretory trypsin inhibitor (PSTI) is an acute phase reactant released from hepatocytes, we investigated the effects of various cytokines on the release of PSTI from cultured human hepatoblastoma cells. PSTI was synthesized in human hepatoblastoma cells a...

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Published inLife sciences (1973) Vol. 43; no. 15; p. 1233
Main Authors Murata, A, Ogawa, M, Uda, K, Matsuura, N, Watanabe, Y, Baba, T, Mori, T
Format Journal Article
LanguageEnglish
Published Netherlands 1988
Subjects
Biological Factors - pharmacology
Carcinoma, Hepatocellular - metabolism
Cytokines
Humans
Interferon Type I - pharmacology
Interleukin-1 - pharmacology
Liver Neoplasms
Pancreas - enzymology
Recombinant Proteins
Trypsin Inhibitors - metabolism
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha - pharmacology
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Summary:To determine whether or not human pancreatic secretory trypsin inhibitor (PSTI) is an acute phase reactant released from hepatocytes, we investigated the effects of various cytokines on the release of PSTI from cultured human hepatoblastoma cells. PSTI was synthesized in human hepatoblastoma cells and released on stimulation with various cytokines: interleukin-1, tumor necrosis factor and interferon-beta.
ISSN:0024-3205
DOI:10.1016/0024-3205(88)90213-5