The accumulation of basement membrane components during the onset of chondrogenesis and myogenesis in the chick wing bud

The study describes the distribution of several basement membrane molecules in the embryonic chick wing bud from stages 23 to 26, during the onset of myogenesis and chondrogenesis, and then later at stage 28. Laminin is localized as early as stage 23, prior to the onset of myogenesis, in regions cor...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 104; no. 1; pp. 41 - 49
Main Authors Solursh, M, Jensen, K L
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Limited 01.09.1988
Subjects
Animals
Basement Membrane - embryology
Basement Membrane - metabolism
Cartilage - embryology
Chick Embryo
Collagen - metabolism
Laminin - metabolism
Muscles - embryology
Wings, Animal - embryology
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Summary:The study describes the distribution of several basement membrane molecules in the embryonic chick wing bud from stages 23 to 26, during the onset of myogenesis and chondrogenesis, and then later at stage 28. Laminin is localized as early as stage 23, prior to the onset of myogenesis, in regions corresponding to the position of the future dorsal and ventral myogenic areas. Other matrix components, including fibronectin, do not differentially accumulate in these same regions. Fibronectin, basement membrane heparan sulphate proteoglycan and type IV collagen are more widespread in their distribution than laminin, and are even present between mesenchymal cells. These results suggest a role for laminin in the initial differentiation of the muscle masses and emphasize that components of basement membrane can also be associated with mesenchymal cells.
ISSN:0950-1991
1477-9129
DOI:10.1242/dev.104.1.41