Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness

• Published in: Pharmacological research Vol. 31; no. 6; pp. 387 - 392
• Main Authors: Asti, C., Melillo, G., Caselli, G.F., Daffonchio, L., Clavenna, G., Omini, C., Hernandez, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.1995
• Subjects: Acetylcholine - pharmacology; airway hyperreactivity; Animals; Carbocysteine - pharmacology; carbocysteine lysine salt monohydrate; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation - drug therapy; Interleukin-1 - pharmacology; lung inflammation; Lysine - pharmacology; Rats; Respiratory Hypersensitivity - drug therapy; Respiratory System - drug effects; airway hyperreactivity; carbocysteine lysine salt monohydrate; lung inflammation
• ISSN: 1043-6618; 1096-1186
• DOI: 10.1016/1043-6618(95)80094-8

We investigated the possible effects of the mucoactive drug Carbocysteine lysine salt monohydrate (CLS.H 2O) on experimentally-induced airway inflammation and hyperresponsiveness. CLS.H 2O given by the oral route (300 mg kg −1 significantly reduced neutrophil infiltration into the airway lumen induced by intratracheal injection of IL-1β in rats. In addition, CLS.H 2O inhibited dose-dependently (100–300 mg kg −1 p.o.) the formation of pleural exudate and leukocyte recruitment induced by intrapleural injection of carrageenan in rats. Because of the close, interaction between the inflammatory process and the development of airway hyperresponsiveness we also tested CLS.H 2O on cigarette-smoke-induced inflammation and hyperreactivity in anaesthetized guinea-pigs. The drug, given either by oral (300 mg kg −1) or aerosol route (30–100 mg ml −1), was able to reduce the increase in airway responsiveness induced by smoke and the associated cell recruitment detected in the bronchoalveolar lavage (BAL) fluids. These results suggest that CLS.H 2O can exert an anti-inflammatory action in addition to its mucoregulatory activity. The anti-inflammatory and anti-hyperreactivity effect of the drug within the airways may be of advantage in the treatment of inflammatory lung diseases where mucus secretion together with airway inflammation and hyperreactivity contribute to airway obstruction.