The design and synthesis of substituted biphenyl libraries

• Published in: Bioorganic & medicinal chemistry Vol. 4; no. 5; pp. 659 - 666
• Main Authors: Pavia, Michael R., Cohen, Michael P., Dilley, Garrett J., Dubuc, Gloria R., Durgin, Tracy L., Forman, Frank W., Hediger, Mark E., Milot, Guy, Powers, Timothy S., Sucholeiki, Irving, Zhou, Shulan, Hangauer, David G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.1996
• Subjects: biphenyl; Biphenyl Compounds - chemical synthesis; Biphenyl Compounds - chemistry; Chromatography, High Pressure Liquid - methods; Drug Design; library; Magnetic Resonance Spectroscopy; multiple simultaneous synthesis; solid-phase synthesis; biphenyl; library; solid-phase synthesis; multiple simultaneous synthesis
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/0968-0896(96)00060-0

A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening. A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for displays of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected.