Reversal of dilated cardiomyopathy after chronic tricyclic antidepressant drug withdrawal

Two patients referred for heart transplantation for dilated cardiomyopathy on chronic tricyclic antidepressant treatment are described. Echocardiographic normalization of left ventricular diameters and function were evidenced after drug withdrawal, suggesting drug-induced toxic myocardial disease. T...

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Bibliographic Details
Published inInternational journal of cardiology Vol. 48; no. 2; pp. 192 - 194
Main Authors Martí, Vicens, Ballester, Manel, Obrador, Damià, Udina, Claudi, Moya, Concepción, Pons-Lladó, Guillem
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.02.1995
Subjects
Antidepressive Agents, Tricyclic - adverse effects
Antidepressive Agents, Tricyclic - therapeutic use
Cardiomyopathy, Dilated - chemically induced
Cardiomyopathy, Dilated - diagnostic imaging
Cardiomyopathy, Dilated - physiopathology
Echocardiography
Female
Humans
Middle Aged
Remission, Spontaneous
Reversible dilated cardiomyopathy
Time Factors
Tricyclic antidepressant drugs
Ventricular Function, Left
Reversible dilated cardiomyopathy
Echocardiography
Tricyclic antidepressant drugs
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Summary:Two patients referred for heart transplantation for dilated cardiomyopathy on chronic tricyclic antidepressant treatment are described. Echocardiographic normalization of left ventricular diameters and function were evidenced after drug withdrawal, suggesting drug-induced toxic myocardial disease. The possibility of functional improvement after tricyclic antidepressant drug withdrawal should be kept in mind before including patients with dilated cardiomyopathy in a heart transplantation program.
ISSN:0167-5273
1874-1754
DOI:10.1016/0167-5273(94)02231-7