Sjögren's syndrome in progressive systemic sclerosis (scleroderma)
Sicca features of Sjögren's syndrome were investigated in 25 consecutive patients with progressive systemic sclerosis by means of clinical examination, Schirmer's tests, rose bengal staining tests, secretory parotid sialographies, scintillation scanning of salivary glands with 99-mTc perte...
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Published in | The American journal of medicine Vol. 57; no. 1; pp. 78 - 85 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.07.1974
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Subjects | |
Online Access | Get full text |
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Summary: | Sicca features of Sjögren's syndrome were investigated in 25 consecutive patients with progressive systemic sclerosis by means of clinical examination, Schirmer's tests, rose bengal staining tests, secretory parotid sialographies, scintillation scanning of salivary glands with 99-mTc pertechnetate, radionuclide salivary excretion studies and lip biopsies for study of minor salivary glands.
All 25 patients had at least one abnormal test and all but 3 patients had more than two abnormal tests.
Pathologic findings in minor salivary glands included both lymphocytic infiltration and duct cell proliferation characteristic of Sjögren's syndrome, as well as collagen infiltration and disruption attributable to scleroderma. However, the finding of lacrimal and major salivary gland involvement indicates that Sjögren's syndrome does occur in the majority of patients with progressive systemic sclerosis. Because Sjögren's syndrome coexists almost exclusively with autoimmune disorders, our findings support the contention that progressive systemic sclerosis is related to autoimmunity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-9343 1555-7162 |
DOI: | 10.1016/0002-9343(74)90771-2 |