Heterochromatin formation: role of short RNAs and DNA methylation

The role of small double-stranded RNAs is considered in formation of silent chromatin structure. Small RNAs are implicated in the regulation of individual gene transcription, suppression of transposon expression, and in maintaining functional structure of extended heterochromatic regions. Interrelat...

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Bibliographic Details
Published inBiochemistry (Moscow) Vol. 70; no. 11; pp. 1187 - 1198
Main Authors Klenov, M S, Gvozdev, V A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.11.2005
Subjects
Animals
Chromatin
Deoxyribonucleic acid
DNA
DNA Methylation
DNA Transposable Elements
Gene regulation
Gene Silencing
Genetics
Heterochromatin
Heterochromatin - metabolism
Histones
Plants - genetics
Ribonucleic acid
RNA
RNA - physiology
RNA, Double-Stranded - physiology
RNA-mediated interference
Transcription, Genetic
Yeasts - genetics
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Summary:The role of small double-stranded RNAs is considered in formation of silent chromatin structure. Small RNAs are implicated in the regulation of individual gene transcription, suppression of transposon expression, and in maintaining functional structure of extended heterochromatic regions. Interrelations between short RNA-dependent gene silencing, histone modifications, and DNA methylation are discussed. Specific features of RNA-induced chromatin repression in various eucaryotes are also described.
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ISSN:0006-2979
1608-3040
0320-9725
DOI:10.1007/s10541-005-0247-4