Inhibition of insulin release by amylin is not mediated by changes in somatostatin output

We have investigated the effect of a high concentration (750 nM) of synthetic amidated rat amylin on unstimulated somatostatin and insulin secretion as well as on the response of these hormones to arginine. Amylin consistently reduced insulin output but it did not significantly modify somatostatin r...

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Bibliographic Details
Published inLife sciences (1973) Vol. 49; no. 10; p. 761
Main Authors Peiró, E, Dégano, P, Silvestre, R A, Marco, J
Format Journal Article
LanguageEnglish
Published Netherlands 1991
Subjects
Amyloid - pharmacology
Animals
Arginine - pharmacology
Insulin - metabolism
Insulin Antagonists
Insulin Secretion
Islet Amyloid Polypeptide
Male
Rats
Rats, Inbred Strains
Somatostatin - antagonists & inhibitors
Somatostatin - metabolism
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Summary:We have investigated the effect of a high concentration (750 nM) of synthetic amidated rat amylin on unstimulated somatostatin and insulin secretion as well as on the response of these hormones to arginine. Amylin consistently reduced insulin output but it did not significantly modify somatostatin release. These findings indicate that the inhibitory effect of amylin on insulin secretion is not mediated by a D-cell paracrine effect.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(91)90109-O