Peripheral venous scintillation angiocardiography in determination of left ventricular volume in man

• Published in: The American journal of cardiology Vol. 28; no. 5; pp. 563 - 567
• Main Authors: Sullivan, Robert W., Bergeron, Dale A., Vetter, William R., Hyatt, Kenneth H., Haughton, Victor, Vogel, John M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.1971
• Subjects: Angiocardiography; Cardiac Catheterization; Cardiac Volume; Coronary Circulation; Heart Diseases - physiopathology; Heart Ventricles - physiopathology; Humans; Image Enhancement; Radiometry; Technetium
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/0002-9149(71)90098-1

Left ventricular end-diastolic volume was determined by cardiac visualization after peripheral venous injection of a gamma-emitting isotope in 10 patients with organic heart disease. The patients included 5 with aortic insufficiency, 2 with aortic stenosis and 3 with cardiomyopathy. Ten millicuries of technetium-99m, 10 mc in a volume of 1 ml, was injected into an antecubital vein. Sequential single plane images in the right anterior oblique projection were displayed on the oscilloscope of an Anger scintillation camera and were recorded on Polaroid film with exposures integrating counts over serial 2-second intervals. These studies were performed in parallel with left ventricular dye-contrast angiography. A spherical object containing 1 mc of isotope diluted in 200 ml of water was photographed at various distances from the scintillation camera to evaluate distortion and to compute magnification factors. Left ventricular end-diastolic volume was then calculated from X-ray and isotope records by the formula V = π 6L M 2 , where L equals the longest measured axis, and M equals the minor axis, bisecting and perpendicular to L. The left ventricular end-diastolic volume measured by the isotope method consistently averaged 9 percent less than that determined by the X-ray method (mean 206 and 227 ml, respectively). The mean difference in left ventricular end-diastolic volume was 21 ml (range 3 to 39 ml). Excellent correlation (r = 0.993) between the 2 methods was observed. Peripheral venous scintillation angiocardiography compares well with left ventriculography in determination of left ventricular end-diastolic volume in man.