Effect of some β-carbolines on phenylethylamine and apomorphine stereotypies in rats

Tetrahydro-β-carbolines (THBC:s) have recently been shown to occur in the human body and their role in mental diseases has been discussed. The effect of THBC:s and some other β-carbolines (25 mg/kg IP) were studied on the stereotypies caused by apomorphine (APO, 2 mg/kg IP) and phenylethylamine (PEA...

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Published inPharmacology, biochemistry and behavior Vol. 12; no. 6; pp. 979 - 982
Main Authors Kari, Ilkka, Rapakko, Seppo, Airaksinen, Mauno M
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.1980
Subjects
Aggression - drug effects
Animals
Apomorphine
Apomorphine - antagonists & inhibitors
Apomorphine - pharmacology
Behavior - drug effects
Carbolines - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Humans
Indoles - pharmacology
Male
Paranoid psychose
Phenethylamines - pharmacology
Phenylethylamine
Rat
Rats
Schizophrenia
Stereotyped Behavior - drug effects
Stereotyped behaviour
Time Factors
Tryptolines
β-Carbolines
Tryptolines
Rat
Schizophrenia
Phenylethylamine
Stereotyped behaviour
β-Carbolines
Paranoid psychose
Apomorphine
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Summary:Tetrahydro-β-carbolines (THBC:s) have recently been shown to occur in the human body and their role in mental diseases has been discussed. The effect of THBC:s and some other β-carbolines (25 mg/kg IP) were studied on the stereotypies caused by apomorphine (APO, 2 mg/kg IP) and phenylethylamine (PEA, 50 mg/kg IP) in rats. These effects of dopaminergic drugs like apomorphine as well as of phenylethylamine have sometimes been used as animal models of paranoid schizophrenia. Dose effect relationships were studied from the most potent substances. All β-carbolines studied significantly inhibited APO stereotypy. 6-Methoxyharmalan was most effective followed by β-carboline (BC), tetrahydro-β-carboline (THBC), 1-methyl-THBC, 6-methoxy-THBC and 6-hydroxy-THBC. 6-Methoxyharmalan, 6-hydroxy-THBC and BC inhibited also PEA stereotypy. Other substances studied were ineffective. β-Carbolines did not inhibit PEA and APO stereotypies in the same way. Thus the mode of PEA and APO stereotypies seems to differ, and β-carbolines seem influence these stereotypies by more than one mechanism. If dopamine hypothesis is valid, the β-carbolines formed in human body may protect rather than worsen in paranoid psychoses.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(80)90462-1