Effect of some β-carbolines on phenylethylamine and apomorphine stereotypies in rats
Tetrahydro-β-carbolines (THBC:s) have recently been shown to occur in the human body and their role in mental diseases has been discussed. The effect of THBC:s and some other β-carbolines (25 mg/kg IP) were studied on the stereotypies caused by apomorphine (APO, 2 mg/kg IP) and phenylethylamine (PEA...
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Published in | Pharmacology, biochemistry and behavior Vol. 12; no. 6; pp. 979 - 982 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.06.1980
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Subjects | |
Online Access | Get full text |
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Summary: | Tetrahydro-β-carbolines (THBC:s) have recently been shown to occur in the human body and their role in mental diseases has been discussed. The effect of THBC:s and some other β-carbolines (25 mg/kg IP) were studied on the stereotypies caused by apomorphine (APO, 2 mg/kg IP) and phenylethylamine (PEA, 50 mg/kg IP) in rats. These effects of dopaminergic drugs like apomorphine as well as of phenylethylamine have sometimes been used as animal models of paranoid schizophrenia. Dose effect relationships were studied from the most potent substances. All β-carbolines studied significantly inhibited APO stereotypy. 6-Methoxyharmalan was most effective followed by β-carboline (BC), tetrahydro-β-carboline (THBC), 1-methyl-THBC, 6-methoxy-THBC and 6-hydroxy-THBC. 6-Methoxyharmalan, 6-hydroxy-THBC and BC inhibited also PEA stereotypy. Other substances studied were ineffective. β-Carbolines did not inhibit PEA and APO stereotypies in the same way. Thus the mode of PEA and APO stereotypies seems to differ, and β-carbolines seem influence these stereotypies by more than one mechanism. If dopamine hypothesis is valid, the β-carbolines formed in human body may protect rather than worsen in paranoid psychoses. |
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ISSN: | 0091-3057 1873-5177 |
DOI: | 10.1016/0091-3057(80)90462-1 |