Distribution of S-100 protein outside the central nervous system

• Published in: Brain research Vol. 234; no. 2; p. 309
• Main Authors: Stefansson, K, Wollmann, R L, Moore, B W
• Format: Journal Article
• Language: English
• Published: Netherlands 25.02.1982
• Subjects: Adrenal Medulla - metabolism; Animals; Ganglia, Autonomic - metabolism; Ganglia, Spinal - metabolism; Humans; Myelin Sheath - metabolism; Nerve Tissue Proteins - metabolism; Nervous System - metabolism; Peripheral Nerves - metabolism; Rats; Rats, Inbred Strains; S100 Proteins - metabolism; Schwann Cells - metabolism
• ISSN: 0006-8993
• DOI: 10.1016/0006-8993(82)90871-X

The distribution of S-100 outside the central nervous system in humans and rats was explored using antiserum to S-100 and the peroxidase anti-peroxidase method of Sternberger. In peripheral nerves the Schwann cells and the outermost part of the myelin sheaths were stained; axons were not. In dorsal root ganglia and ganglia of the autonomic nervous system only satellite cells were stained. In the adrenal medulla a considerable number of cells were stained. In all other organs studied Schwann cells and satellite cells of ganglia were the only elements that were stained. We conclude that S-100 could serve as a marker for Schwann cells in situ.